Evidence that Growth Hormone-Releasing Factor Stimulates Somatostatin Releasein Vitrovia β-Endorphin
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چکیده
منابع مشابه
Regulation of growth hormone secretion from human fetal pituitaries: interactions between growth hormone releasing factor and somatostatin.
Using an explant culture system, we have demonstrated that human somatotropes respond to growth hormone releasing factor (GRF) and somatostatin (SRIF) from as early as 9.5 weeks of fetal age. Responsiveness to GRF increases significantly as a function of age up to midgestation while SRIF inhibition of basal growth hormone (GH) release does not change. SRIF has little effect on GRF-stimulated GH...
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Growth hormone (GH) secretory patterns were studied in a patient with ectopic growth hormone releasing factor (GRF) secretion and in normal men given continuous infusions of human growth hormone releasing factor (1-40)-OH (hGRF-40). In the patient with ectopic GRF secretion, GH secretion was pulsatile despite continuously elevated immunoreactive GRF levels. To determine if pulsatile GH secretio...
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Leptin is a hormone secreted by the adipocytes that regulates food intake and energy expenditure. It is known that growth hormone (GH) secretion is markedly influenced by body weight, being suppressed in obesity and cachexia, and recent data have demonstrated that GH release is regulated by leptin levels. Although one of the sites of action of leptin is likely to be the hypothalamus, since lept...
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Résumé. Vingt-six truies en lactation ont reçu les traitements suivants : 1) solution saline physiologique ; 2) somatocrinine ou hGRF(1-29)NH 2(20 ¡lg.kg1) ; 3) thyréolibérine (TRF) (1 ¡lg.kg) ; 4) combinaison de GRF et de TRF (20 et 1 ¡lg.kgrespectivement). La solution saline ou les peptides ont été injectés par voie sous-cutanée, deux fois par jour, du 5e au 25e jour post-partum. Les niveaux ...
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It is known that leptin, an adipocyte-derived hormone, exerts a stimulatory effect on growth hormone (GH) secretion in various animal species. However, no previous study examined in vivo whether leptin affects the secretion of GH-releasing factor (GRF), somatostatin (SRIH), and some other closely relevant neurohormones in the hypothalamus. Therefore, in this study we investigated the effects of...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1987
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo-120-1-341